Pain in the middle of the two breasts needs to be divided into different conditions, either pain in the soft tissues of the chest wall, pain in the tissues and organs of the chest, or pain in the skin. The part between the two breasts includes not only a part of the chest but also a part of the digestive tract, so a lesion of an organ in the chest cavity or a lesion of the gastroesophagus can cause pain to occur. The simplest cause of pain may be trauma to the skin or insect bites. Secondly, pain may be caused by irritation of the sternum or intercostal nerves. Intra-thoracic organs, such as cardiac myocardial ischemia leading to angina; or lesions of large blood vessels such as aortic coarctation, aortic aneurysm; pleurisy, pneumothorax; or gastric perforation, gastric spasm, gastroesophageal reflux disease, esophagitis. The nature, degree, and duration of pain caused by various lesions are different and also need to be seen in conjunction with other symptomatic manifestations or examination tests to determine the cause. In summary, pain in the middle of both breasts includes more causes, such as angina pectoris, gastroesophageal reflux, gastric perforation or spasm, large vessel lesions, pneumothorax and other complex or crisis situations, and if there is no relief in a short time, it is best to check the cause and treat it promptly.