Enema is a treatment for inflammation of the lower gastrointestinal tract such as the rectum, sigmoid colon and left hemicolectum. It uses an anal tube, coated with a small amount of paraffin oil, which is lubricated and then gently inserted through the anus to make contact with the rectal mucosa, sigmoid mucosa, and even the descending colon mucosa, and then instills the drug from the anal tube into the mucosa of the intestines it contacts. Usually, for ulcerative colitis, left hemicolectomy and rectosigmoiditis, enemas are often used to treat the disease, and local treatment with mesalazine or symptomatic mucosal protectants and symptomatic drugs is much more effective than oral administration. Because oral administration is not able to reach the specific amount of medication for the distal colon, while enemas are a better treatment method by directly contacting the location of the lesion.