Patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) are mostly older, and at present, patients in the early stage are not treated by observation and waiting, and chemotherapy is administered after disease progression, which has more toxic side effects and poor efficacy. We have developed a herbal formula for the treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma (and follicular lymphoma), Twelve Flavors Eliminate Lymphatic San, which is based on the traditional formula of Siwu Xie Scrofula Tang, and based on the results of our long-term clinical practice, we have added several herbal medicines that can target the removal of mature lymphocytes, so as to support the positive and eliminate the evil. The two-pronged approach can nourish the blood, invigorate the blood, nourish the liver and nourish the kidney, and at the same time can gently and effectively reduce the tumor load and slow down the progression of tumor deterioration.