For patients with cirrhosis to develop splenomegaly is a serious disease. If a patient with cirrhosis has developed splenomegaly, it means that it is in the decompensated stage, because of the development of portal hypertension, so it will cause the enlargement of the spleen and also the development of esophagogastric-fundic varices, and the rupture of esophagogastric-fundic varices is a very common cause of upper gastrointestinal bleeding. For cirrhosis splenomegaly, patients must cooperate with the specialist to give regular treatment, to remove the cause of the disease, but also actively treat the primary disease, and cooperate with the specialist to give liver protection medication. If ascites is present, diuretic and portal pressure lowering treatments are also needed, and the specialist should be consulted for details. Overall, patients with cirrhosis, especially those who have developed splenomegaly, must pay high attention and cooperate with the specialist for regular drug treatment.