Arteriosclerosis of the lower limbs in diabetic patients is generally not edema caused by increased vascular permeability, but mostly caused by arterial ischemia and vascular stenosis. Diabetic lower limb atherosclerosis is due to long-term poor glycemic control, resulting in arterial wall lipid deposition, vascular endothelial function is impaired, which can easily lead to thrombosis, resulting in local blood flow stenosis and occlusion, a series of clinical manifestations of lower limb ischemia. Diabetic lower limb atherosclerosis belongs to the vascular complications of diabetes mellitus, long-term poor control of blood glucose, there will be microcirculation disorders, microvascular occlusion, atherosclerosis of the large blood vessels, resulting in narrowing of the lumen and poor blood flow. Easily manifested as intermittent claudication, walking for a period of time due to lower limb ischemia appeared in both legs pain, relieved after rest. It is recommended that diabetic patients actively control blood glucose, atherosclerosis timely medical treatment.