Generally cholinergic urticaria is not hereditary, and the disease is mainly related to exercise, stress and heat exposure. Cholinergic urticaria is mainly associated with exercise, stress, emotional stress, wearing tight clothing, drinking hot drinks or ingesting spicy and irritating food, the deep body temperature rises to cause cholinergic nerve impulses and the release of acetylcholine, and act on mast cells and the onset of the disease. Therefore, genetic factors are not the main cause of cholinergic urticaria. Cholinergic urticaria is most common in young patients, and may be characterized by the appearance of localized round papular eruptions 1 to 3 mm in diameter, with varying degrees of redness around them. Patients are also prone to itchy, burning sensation, but no skin lesions. At the same time, some patients with severe cholinergic urticaria are also prone to headache, tearing, abdominal pain and other discomforts. It is recommended that people diagnosed with cholinergic urticaria actively cooperate with the doctor’s treatment, do not use drugs or prescriptions. Pay attention to daily skin care, try to wear loose, pure cotton clothing.