Diabetic foot patients with toenail detachment need to be first medication for anti-inflammatory sterilization, the situation is serious need to carry out surgical treatment. Toenail detachment in diabetic foot patients can be locally disinfected and sterilized, and then use some ointment with antiseptic and disinfectant effects. If gangrene forms or affects normal walking, surgery can be performed to remove the gangrenous area to avoid progression of the lesion. Diabetic foot is caused by the combined effect of diabetic microvascular lesions, macrovascular lesions and neurological lesions, plus local infections, so the treatment firstly needs to control the blood glucose, and insulin is usually used to control the blood glucose. If a diabetic foot patient has severe symptoms of toenail loss, or if the symptoms persist and do not improve, he or she should go to the hospital for treatment.