Bone metastasis of lung cancer can usually be treated with intramuscular injection of pamidronate injection or zoledronic acid injection. 1. Pamidronic acid injection: bone metastasis of lung cancer is mainly manifested as pain and dysfunction caused by bone fracture, and patients will have symptoms such as bone pain, skin swelling, pathological fracture, etc. Pamidronic acid injection belongs to anti-bone metastasis drugs, which can alleviate pain of patients. Pamidronate injection belongs to anti-bone metastasis drugs, which can reduce patients’ pain, enhance motor function and reduce complications. 2. Zoledronic acid injection: bone metastasis in lung cancer patients will cause bone pain, zoledronic acid mainly has the function of reducing bone pain caused by malignant bone metastasis, meanwhile, zoledronic acid injection can reduce the symptoms of patients by inhibiting osteoclasts and osteocalcin release. It is recommended that the patient actively cooperate with the doctor’s treatment, keep the mood optimistic, always observe the physical condition, discomfort, timely consultation, active treatment, so as to avoid delaying the condition.