Impotence and premature ejaculation usually does not exist the so-called what is the best medicine to use, impotence may be caused by urethral episiotomy, low androgen levels and other factors, you can generally use androgen drugs such as methyltestosterone, premature ejaculation may be caused by abnormal hormone levels, inflammation of the urethra and other factors, you can generally use proparacaine and other local anesthetic medications, dapoxetine and other 5-hydroxytryptamine reuptake inhibitors. 1. Androgenic drugs: androgenic drugs usually have methyltestosterone, testosterone enanthate, etc., generally can increase the level of androgens, improve the inability to erection and other symptoms, the use of improper use of rashes, pain in the lower limbs and other symptoms, drug allergy is prohibited. 2. local anesthetic drugs: local anesthetic drugs generally have proparacaine, benzocaine, etc., usually can reduce penile sensitivity, improve premature ejaculation and other symptoms, the use of improper use may have a headache, weakness and other symptoms, drug allergy is prohibited. 3. 5-hydroxytryptamine reuptake inhibitors: 5-hydroxytryptamine reuptake inhibitors usually have dapoxetine, paroxetine, etc., usually can delay ejaculation, improve premature ejaculation. Improper use may cause adverse reactions such as headache, dizziness, nausea, and diarrhea. The drug is contraindicated in people with a known allergy to the product, in patients with a significant pathological condition of the heart, in patients with moderate and severe liver damage. The drug should also not be used in conjunction with thioridazine, strong cytochrome P450 3A4 inhibitors, and monoamine oxidase inhibitors. Patients should consult a doctor in time and use the drug rationally under the doctor’s guidance.