Once Parkinson’s disease is diagnosed, patients will not be able to live without medication for the rest of their lives, and as their disease progresses and worsens, the medication they take will gradually increase and the dose will increase. This is something that many patients and their families resist because they are afraid of the side effects of the medication, and many patients even reduce the dosage without permission when they feel better. Can Parkinson’s patients reduce their medications after they get better? Due to the chronic progressive nature of Parkinson’s disease, doctors prescribe medication to patients based on the age, severity and physical condition of each patient to give the appropriate medication and dose, following the “individualized precision medication”, that is, the smallest dose for each patient to get the maximum improvement effect. Parkinson’s disease patients follow scientific and reasonable medication, not only to effectively control the symptoms, but also to delay the progression of the disease, delay or reduce the emergence of motor complications. Currently, there are clinical relapsed levodopa drugs, which replenish the lack of dopamine neurotransmitters in the brain, and anticholinergic drugs, which inhibit the excitation of acetylcholine and keep it in balance with dopamine levels, as well as many extended-release agents, all types of drugs play different roles, and basically every Parkinson’s disease requires a combination of drugs as the disease progresses. The combination of drugs involves many problems, because each drug has its own role, and each brings side effects and contraindications, which drugs can be combined? The dose of each drug requires the guidance of a professional physician, so patients should not add or subtract drugs without permission. It is also not right to stop the medication suddenly, even if the symptoms improve, because some drugs can be stopped, while others need to be slowly reduced to stop. Patients who want to stop taking medication should consult a medical professional before deciding whether to stop. In addition, there is a “honeymoon period” for medication, usually 3 to 5 years, when the medication is effective. Later, as the disease slowly progresses, the patient’s body develops drug resistance, the drug effect decreases, the onset of action is slow, the maintenance time of the drug effect is shortened, and some patients experience motor complications, i.e., the “end-of-dose phenomenon”, “switch phenomenon”, and “isokinetic disorder”. Some patients develop motor complications, i.e., “end-of-dose phenomenon,” “switch phenomenon,” and “isokinetic disorder,” and the effect of drug adjustment is poor. When Parkinson’s disease has developed to this period, it is also the appropriate period for surgical intervention. Clinically, deep brain electrical stimulation is used to treat the patient, and after surgery, the patient’s limb tremor, stiffness, slow movement, abnormal posture and gait can be improved comprehensively, so that the patient’s symptoms will be in a stable state for several years or more than ten years, and after the postoperative stimulation is stabilized, the amount of medication can also be reduced, thus improving the reduction of drug side effects.