Intermediate-differentiated cancer is a type of cancer. Tumors can be divided into four types according to the degree of differentiation, which are highly differentiated, intermediate, low differentiated and undifferentiated. Among them, hypofractionated and undifferentiated cancers are the types of cancer with high malignancy and low cure rate, while moderately differentiated cancers are relatively less malignant and highly differentiated cancers are the least malignant. The treatment mode and recovery difficulty of cancer are not only related to the degree of differentiation, but also to the location, size, degree of invasion and whether the cancer is metastatic or not. Usually, moderately differentiated cancer without metastasis or lesions can be treated surgically, for example, moderately differentiated adenocarcinoma of the colon, while if the cancer is more extensive or has distant metastasis, it is more difficult to treat, for example, moderately differentiated hepatocellular carcinoma with intrahepatic metastasis. Intermediate-differentiated carcinoma is more likely to metastasize compared to highly differentiated carcinoma, but there is no absolute clinical situation. It still needs to be combined with the location of cancer, examination results, and patient’s physical condition to determine the treatment plan. Usually, the malignancy degree of medium fractionated cancer is only higher than that of high fractionated cancer, and the prognosis is better than other cases.