Creatinine 350μmmol/L usually refers to blood creatinine, the normal value of blood creatinine standard is 44-133μmmol/L, blood creatinine reaches 350μmmol/L, suggesting the existence of renal impairment, if acute renal insufficiency, acute renal failure due to the injury can be controlled, if it is due to chronic kidney disease can not be completely controlled. I. Can be controlled: 1. Acute renal insufficiency: the factors of acute renal insufficiency are categorized into pre-renal, renal and post-renal factors. Especially pre-renal and post-renal factors, resulting in inadequate renal perfusion or urinary tract obstruction, pre-renal and post-renal causes are actively removed, the patient’s renal function can be fully restored, blood creatinine 350μmmol/L can be controlled, usually the earlier the treatment, the better the results; 2, acute renal failure: acute renal failure due to inadequate renal perfusion, or urinary tract obstruction resulting in severe renal function injury. Need to actively find the cause to be treated, after removing the cause of the disease, most of the patients’ blood creatinine will fall back, and even can be completely normalized, blood creatinine 350μmmol/L can be controlled. Uncontrollable: If the patient is chronic kidney disease, such as chronic renal insufficiency, the condition is slowly progressing, glomerulonephrosis, interstitial fibrosis and tubular atrophy, and even symptoms of renal failure, which are irreversible lesions. Therefore, even if the cause of the disease is removed, the blood creatinine cannot be restored to normal, but can only control the complications and comorbidities and slow down the progress of the disease. Creatinine 350μmmol / L, in addition to targeted treatment as prescribed by the doctor, daily life should also protect the kidneys, pay attention to clean and hygienic diet, do not eat spicy and stimulating food, to ensure sufficient rest, to avoid exertion, prohibit smoking and alcohol, to prevent infections, diarrhea and other exacerbation of renal injury, so that the blood creatinine further increase.