Gallbladder carcinoma in situ is a cancer, but it does not need to be operated, only need to remove the gallbladder at an early stage to prevent metastasis and recurrence. It is very difficult to detect carcinoma in situ of gallbladder before operation, and is usually detected by routine pathologic examination after cholecystectomy. The common cause of carcinoma in situ of gallbladder is mucosal carcinogenesis due to repeated stimulation of gallbladder wall by gallbladder stones and gallbladder polyps. Cancer cells are confined to the mucosal epithelium of gallbladder wall without breaking through the basement membrane, and there is no metastasis to neighboring organs, lymph node metastasis, or distant metastasis. If carcinoma in situ is identified, early surgical resection is needed once it is detected. Generally, transperitoneal laparoscopic cholecystectomy is feasible, and pathology is sent to the hospital for testing after surgery, and no radiotherapy or chemotherapy is needed after surgery. It is recommended to go to the hospital as early as possible to avoid delaying the disease.