The two-and-a-half pair, or hepatitis B two-and-a-half pairs, refers to the five indicators of hepatitis B virus, including hepatitis B surface antigen, hepatitis B surface antibody, hepatitis B E antigen, hepatitis B E antibody, and hepatitis B core antibody. If the report card shows that the hepatitis B surface antigen, hepatitis B E antibody and hepatitis B core antibody are positive at the same time, then the test is for hepatitis B minor triple positive. If hepatitis B surface antigen, hepatitis B E antigen, and hepatitis B core antibody are positive, the patient is a major hepatitis B triple-positive. If the patient is a minor hepatitis B triple-positive, this may indicate that the hepatitis B virus is replicating in the body and there is varying degrees of damage to the liver cells. It is usually asymptomatic, but can increase the chance of cirrhosis, liver cancer and other pathologies. The goal of treatment is to suppress or eliminate the hepatitis B virus for a long time, to delay and stop the progression of the disease, to reduce the occurrence of complications such as cirrhosis and hepatocellular carcinoma, to maximize the patient’s quality of life, and to prolong survival. If the patient has no obvious symptoms, treatment is usually not necessary and regular follow-up is sufficient. If patients develop symptoms such as fever, loss of appetite, vomiting, jaundice, etc., they need to go to the hospital in time and adjust the treatment plan according to the situation under the guidance of professional doctors, combining anti-viral therapy, anti-fibrosis, immunomodulation and symptomatic treatment.