Correct use of both TCM remedies and attacking evil to treat tumors

According to TCM, there are various causes of tumors, such as deficiency of vital energy, imbalance of internal organs, and invasion of external evil, which eventually lead to phlegm, stasis, and toxicity, and the coalescence of these three factors results in tumors. The focus of TCM treatment is also on these three factors. Ancient and modern Chinese medicine treatment for tumors can be summarized into two methods: tonicity and attacking evil. The latter can be subdivided into methods of activating blood circulation and removing blood stasis, detoxifying, dispersing nodules, clearing heat, resolving phlegm and so on. These treatments are often compatible with each other and appear in the prescription at the same time. The clinical application of these treatments should pay attention to the identification of evidence, and the wrong application can cause harm to patients. Now, according to my clinical experience, I would like to discuss the use of these treatments. 1.Tonic method According to the efficacy of traditional Chinese medicine, it can be divided into qi tonic, blood tonic, yin tonic and yang tonic. There have been many reports of clinical and experimental studies on the effects of tonic medicines on tumors. For example, most clinical and experimental reports believe that qi tonics (such as ginseng and astragalus) can inhibit the growth of tumors, while a few reports believe that qi tonics have no effect on tumors. We have done animal experiments on the famous qi tonic formula Si Jun Zi Tang. The model animals were tumor-bearing mice (SRS-82), and the tumor inhibition rate of the group fed Si Jun Zi Tang was 15.69%, and the tumor weight was significantly reduced compared with the blank control group, indicating that this formula can directly inhibit tumor growth in vivo. However, compared with the prescription based on attacking evil, the tumor suppression (tumor suppression rate reached 28.45%) of the attacking evil formula was significantly stronger than that of Si Jun Zi Tang. In the apoptosis project of the same experiment, no typical apoptotic changes were seen in the Si Jun Zi Tang group, while obvious characteristic signs of apoptosis appeared in the Attacking Evil formula group. In in vitro serum pharmacology experiments, serum containing Si Jun Zi Tang had no significant inhibitory, killing and apoptosis-inducing effects on cultured tumor cells, although there was no growth-promoting effect, which indicates that tonic drugs have poor effects on tumor cells cultured in vitro. Other reports in the literature indicate that tonic drugs have positive effects on immune function and survival time of tumor-bearing animals in in vivo experiments, suggesting that tonic drugs achieve the purpose of tumor treatment through indirect effects. Thus, the purpose of administering tonic drugs should be to supplement the body and improve immunity, rather than relying on them to directly suppress and kill tumors. There are different views on when tumor patients should use tonic medicine and how much dose should be used. In our opinion, tonic medicine should be used, but the proper time and dose must be mastered, and the evidence must be identified by Chinese medicine. If a tumor patient presents heat toxicity, dampness-heat and other actual heat evidence, it is not appropriate to use tonic medicine, especially warm qi-supplementing medicine. If the patient already has deficiency symptoms, qi tonics or yin tonics can be used as appropriate. Some patients after tumor removal have no more symptoms. As a health care product on weekdays, tonic medicine can be used, but the dosage should not be too large and should not be too rapid and violent. It is better to use less deer antler, gao li ginseng and other overly dry and hot medicines, and more calm and moist medicines such as Ganoderma lucidum, Cordyceps sinensis and American ginseng are appropriate. Although tonic medicines are commonly used in the treatment of tumors, they should not be abused and should only be used as auxiliary medicines. Attacking the evil is the main method to treat tumor, and it is the fundamental method to eradicate tumor or prevent its recurrence. According to the author, tumor occurs under an abnormal functional state, with abnormal functional activities and accumulation of phlegm, stasis and poison over time, which eventually forms tumor. Even if the tumor is surgically removed, this state is not corrected and the foundation of tumor is not eradicated. Therefore, regardless of whether the tumor is surgically removed or not, and regardless of whether chemotherapy is being administered or not, the dysfunction must be corrected with Chinese medicine to eliminate the root cause of the tumor, which is the main task of Chinese medicine treatment. This is the main task of TCM treatment. The method of attacking evil in TCM can accomplish this task very well. The methods of attacking evil include many kinds of methods, the most important ones are blood activation, nodule dispersal and detoxification. When using these methods, attention should be paid to the indications and they should not be abused. These methods are discussed below. 2.1 Blood activation method. Since “blood stasis” is the main cause of tumor, the method of invigorating blood and removing stasis should be used to dispel the stagnation. Most of the clinical prescriptions of anti-tumor herbal medicines use blood-activating drugs. Clinical and animal experiments have reported that many blood-activating drugs have tumor-inhibiting effects, such as Curcuma longa, Salvia miltiorrhiza, Safflower, Peach kernel and so on. However, some scholars have also pointed out that blood-activating and stasis-transforming drugs may accelerate the metastasis of tumors. This point should be given great attention. Accordingly, blood-activating drugs should be used with caution in clinical prescriptions and should not be used in excessive amounts. If they are to be used, it is better to use herbs with stronger tumor suppressing efficacy such as Curcuma longa. 2.2 Detoxification method. Detoxification herbs can be divided into two categories according to toxicity. The more toxic herbs attack the tumor with poison and also have better inhibitory effect on tumor, commonly used are centipede, leech, whole scorpion, spotted worm, turtle worm, yellow medicinal seed and so on. The doses used are reported differently. In the author’s opinion, the dose of these herbs can be increased appropriately for the treatment of tumors, but not in excess. These drugs ultimately depend on the liver for detoxification, so it is advisable to use light dosage for patients with liver tumors, and attention should be paid to whether liver function is impaired during use. Chinese herbs with little or no toxicity also have good detoxification effects, commonly used are half a lotus, half a lotus, white flowered snake’s tongue, piercing lotus, yellow lotus, scutellaria, water hyacinth and so on. These herbs are clinically safe and most commonly used, and the dosage can be increased exponentially, often to more than 30 grams. For some patients with deficiency symptoms, they can still be used in large doses while adding tonic medicines at their discretion. 2.3 Dispersing method. The main purpose of this treatment is to eliminate the mass and eradicate the basis of tumor. This is an important treatment for tumors. Commonly used herbal medicines for dispersing nodules include zhebei mum, fenghuang, bile nancellus, smallpox powder, guajia, lycopodium, yuan shen, xiaquan, forsythia and so on. The dosage of these herbs should also be increased, except for Fuxianxia, Bile South Star and Smallpox Powder, which are slightly toxic, all other drugs can be used up to 30 grams or more. The anti-tumor effect of many drugs in this method has been confirmed by pharmacological experiments. The anti-tumor effects of many drugs in this method have been confirmed by pharmacological experiments. Our anti-tumor formula composed of detoxification and nodule dispersing drugs has achieved good clinical efficacy. In vivo and in vitro animal experiments have proved that the formula can significantly inhibit the growth of tumor cells in tumor-bearing mice (SRS-82) and cultured tumor cells, and has significant apoptosis-inducing effects in vivo and in vitro, and can down-regulate the expression of the apoptosis-inhibiting gene bcl-2, which is superior to qi-supplementing drugs in terms of anti-tumor efficacy. 3.Recommendation of formula In clinical formula, all the above methods can be used in proportion, and the prescription can be combined according to the following principles. (1) Regardless of whether the tumor has been removed or not, whether the patient is under radiotherapy or chemotherapy, as long as the patient does not have deficiency symptoms, the ratio of various types of Chinese medicines in the prescription can be as follows: 1 part of blood activating medicine, 5 parts of detoxifying medicine, 4 parts of nodule dispersing medicine, and no tonic medicine for the time being. (2) When the patient first sees deficiency symptoms, the ratio can be as follows: 1 part of tonics, 1 part of blood activators, 4 parts of antidotes, and 4 parts of nodules dispersers. (3) For those with obvious signs of weakness, 4 parts of tonics, 3 parts of antidotes, and 3 parts of dispersions are available. (4) For patients with extreme weakness, add 6 parts of tonics, 2 parts of antidotes and 2 parts of dispersions.