It is generally considered that antiepileptic drug therapy should be started after the occurrence of a second seizure without an obvious trigger, but in the case of trauma or tumor, the first seizure should be medicated. In addition, some patients who have more than 2 seizures but have an interval of more than a year do not need to take medication for the time being. Monotherapy or combination 70%-80% of patients can control their seizures with monotherapy, but if monotherapy does not control seizures well, a reasonable multi-drug combination should be considered, but it also has more adverse effects and should be adjusted after consulting a specialist. What to do if the seizures cannot be controlled by multi-drug combination therapy 3 appropriate antiepileptic drugs alone or in combination still cannot control the seizures well, then the hope of further drug therapy is less than 5%, and it is considered drug-refractory epilepsy, then surgery needs to be considered for preoperative evaluation. Considerations for medication reduction and discontinuation After more than 2-5 years of complete absence of seizures, medication can be considered to be discontinued. Discontinuation should be done slowly, only one drug should be reduced at a time, and at least one month interval should be allowed after withdrawal of one drug, and if there is still no seizure, then the second drug should be withdrawn.