The best time to deal with hypoglycemia in newborns is the earlier the better to avoid serious sequelae from hypoglycemia. Usually, some newborns can develop transient hypoglycemia after birth, which can be quickly recovered by giving milk and sugar water. If a newborn has some perinatal high-risk factors, such as mother’s diabetes or congenital genetic metabolic or endocrine diseases that lead to low blood sugar, it is necessary to pay attention to it and promptly visit neonatology or pediatrics to treat the primary disease, otherwise it can cause brain cell damage and leave irreversible neurological damage. In addition, for newborns, attention should be paid to strengthening warmth and reducing energy consumption to prevent hypoglycemia.