Neonatal hypoglycemia refers to the blood glucose lower than the minimum blood glucose value of normal newborns caused by various reasons. At present, the diagnosis of hypoglycemia is mostly made by whole blood glucose lower than 2.2mmol/L at home and abroad, and lower than 2.6mmol/L as the threshold value that needs clinical treatment. Since neonatal hypoglycemia can cause irreversible brain damage, it is important to pay attention to it. Generally, the damage to the brain tissue depends on the severity and duration of hypoglycemia, so the baby with hypoglycemia should be treated in time to avoid persistent hypoglycemia. 1, asymptomatic hypoglycemia: can be advanced food, and closely monitor blood sugar, hypoglycemia can not be corrected can be intravenous infusion of glucose. For newborns who may have hypoglycemia, start feeding 10% glucose 1 hour after birth, and start feeding milk 2 to 3 hours after birth. 2. Symptomatic hypoglycemia: intravenous glucose infusion is needed, and micro glucose is monitored every hour during treatment. If symptoms disappear and blood glucose is normal, glucose infusion is gradually reduced to stop, and breastfeeding is promptly given. The physiological requirement of sodium chloride and potassium chloride should be given 24 to 48 hours after birth. If the persistent hypoglycemia lasts for a long time, hydrocortisone or oral prednisone (prednisone) can be added, and the dosage should be gradually reduced after the blood sugar is normal. Very low weight premature infants have poor tolerance to sugar, and attention should be paid to the infusion speed when infusing glucose. 3. Persistent or recurrent hypoglycemia: For children with recurrent or persistent hypoglycemia, blood insulin, hyperglycemia, T4, TSH, growth hormone and cortisol should be measured. Measure blood and urine amino acid and organic acid if necessary. Abdominal ultrasound or CT examination should be done to investigate whether there is islet cell hyperplasia or islet adenoma. The treatment should pay attention to increase the rate of glucose infusion, and intravenous glucagon can also be injected. For hyperinsulinemia, diazoxide can be used; for islet cell hyperplasia, subtotal pancreatic resection is required; children with congenital metabolic defects are given special dietary therapy.