Most patients with hypertension show an arytenoid pattern of elevation in the morning, a small decrease after meals, and a significant decrease at night during sleep. In some pathological conditions, such as diabetes mellitus, geriatric hypertension, salt-sensitive or recalcitrant hypertension, the reduction in blood pressure at night is reduced to a non-ascending degree, or even reversed to an anti-ascending pattern. The non-ascending or anti-ascending presentation type is a risk factor for left ventricular hypertrophy, microalbuminuria, cerebrovascular disease, heart failure, vascular dementia and myocardial infarction. Therefore, the modification of these blood pressure conditions is clinically important, and for this reason there is a growing interest in studying the administration of antihypertensive drugs at different times of the day. The pattern of blood pressure fluctuation in humans is determined by the diurnal variation of neurohumoral factors in the body. The morning dose of antihypertensive medication in most hypertensive patients should theoretically apply to arytenoid patients and have the same 24-hour effect as the antihypertensive medication taken. A single dosing regimen is not reasonable in non-arytenoid patients, especially in elderly and diabetic hypertensive patients. Foreign scholars, comparing the effects of calcium antagonists and angiotensin-converting enzyme inhibitors on the circadian rhythm of blood pressure, found that calcium antagonists had little effect on the circadian rhythm of blood pressure whether they were taken in the morning or in the evening, while isoptin extended-release tablets taken in the evening had a negative effect on blood pressure at night. Angiotensin-converting enzyme inhibitors or bedtime dosing both helped improve circadian rhythm changes in hypertensive patients. The angiotensin receptor antagonists colesartan, telmisartan, and olmesartan are also beneficial when taken at bedtime to improve the antihypertensive effect and adjust the circadian type of blood pressure in hypertensive patients. Therefore, angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists a class of antihypertensive drugs taken at night before bedtime is conducive to improving their antihypertensive effect, lowering nighttime blood pressure, improving the circadian rhythm of blood pressure, and contributing to the cardiovascular protective effect. The above study has yet to be confirmed by more clinical observations.