With diabetes creatinine of 547μmol/L is not normal, mostly considered as diabetic nephropathy. Creatinine is the product of human muscle metabolism, and its normal value is 53~106 μmol/L for men and 44~97 μmol/L for women; when the creatinine is 547 μmol/L, it may be caused by renal function damage, and it is mostly considered as diabetic nephropathy. Creatinine is a normal body metabolite, which is excreted through the kidneys. Once the kidney filtration is impaired, the metabolite creatinine accumulates and increases in the blood. The higher the creatinine value, the more serious the kidney function is impaired. When the creatinine of patients with diabetes is 547μmol/L, it is recommended to go to the hospital in time, improve the relevant examinations under the doctor’s guidance, such as renal function, urine biochemistry, blood routine, etc., and actively treat the disease to slow down the progress of the disease.