Patient: Description of the condition (onset time, main symptoms, hospital visited, etc.): Hello, I am 46 years old and on June 1, 2011, after a modified radical right breast surgery under general anesthesia at Wuxi Maternal and Child Health Hospital, the surgery went well. postoperative pathology: (right) mucinous carcinoma of the breast with localized area of intraductal carcinoma grade III. The tumor size was 1*1*1cm. a small amount of localized ductal epithelial papillary hyperplasia with atypical hyperplasia and necrosis, no tumor metastasis in axillary lymph nodes (0/22). er: positive (++), pr: positive (++), C-erbB-2: positive (+). After four times of intravenous chemotherapy, the blood count was normal after the review. The chemotherapy led to fatty liver and diabetes, and now I am taking Bystolic and Tamoxifen citrate tablets, which led to the thickening of the endometrium to 11mm after 5 months of taking them, and then I had a scraping operation on February 4, 2012. Can I continue to take this medicine (Tamoxifen Citrate Tablets)? Is there an alternative medicine with less side effects? Can you tell me about the biological treatment of tumor and the immunization of cells? Zong Xiangyun, Department of Breast Surgery, Shanghai Sixth People’s Hospital: First of all, I would like to correct that “fatty liver and diabetes caused by chemotherapy” should not be the case, but probably surgery and chemotherapy are only a trigger point. Zong Xiangyun, Department of Breast Surgery, Shanghai Sixth People’s Hospital: It is true that a larger proportion of patients taking tamoxifen after breast cancer surgery develop endometrial thickening, which objectively has an increased risk of endometrial lesions. However, because a large number of clinical trials over the years have confirmed that tamoxifen as an adjuvant endocrine therapy drug can improve the survival rate and reduce the recurrence and metastasis rate of breast cancer after surgery, we believe that the pros and cons are weighed against each other, and it is still recommended to take it if there are no obvious adverse effects. Zong Xiangyun, Department of Breast Surgery, Shanghai Sixth People’s Hospital: In your case, the endometrial thickening is obvious and you have already scraped the uterus once, so my suggestion has several options: 1. 3, some cases can be used Favis Group