Pharyngeal reflux disease: a general term for a series of corresponding symptoms and signs of reflux of gastric contents above the upper esophageal sphincter: pharynx, nose, middle ear, trachea, and bronchial area. Clinical manifestations: foreign body sensation in the pharynx, phlegm with mucus-like salty feeling in the pharynx, persistent throat clearing, hoarseness (or dysphonia), throat pain, chronic long-term cough, dyspnea, laryngospasm, and other symptoms, as well as mucosal hyperplasia and hypertrophy in the posterior conjoined region of the vocal cords, diffuse congestion and edema of the vocal cords, and in severe cases, laryngeal signs such as granuloma, loss of laryngeal chambers, and subglottic stenosis. Studies have found that more than 50% of voice disorders are related to pharyngeal reflux. It was previously thought that direct irritation of the mucosa of the pharynx, larynx, and trachea by gastric acid in gastric contents was the main factor in causing these signs and symptoms. There is increasing evidence that these signs and symptoms are the result of the combined action of gastric acid and pepsin in gastric contents. Pathogenesis-related factors: Westernized lifestyle, poor dietary habits and unhealthy diet structure; direct damage to the mucosa of the pharynx and surrounding tissues by gastric acid-pepsin. The pharyngeal mucosa is more sensitive to gastric acid than the esophagus and lacks resistance mechanisms to gastric acid. Possible diseases associated with pharyngeal reflux are: reflux laryngitis, vocal cord nodules, vocal cord polyps, laryngeal cancer, contact granuloma of the vocal cord, subglottic stenosis, vocal cord leukoplakia, paradoxical movements of the vocal cord, laryngospasm, dysphagia, vocal cord Renk’s edema, chronic cough, asthma, rhinitis-sinusitis, otitis media, OSAHS. Diagnosis: 24h pharyngeal reflux events > 3 times are diagnostic; pharyngeal pH monitoring : Diagnosis is made by Ryan index >9.41 in upright position and/or >6.79 in recumbent position. Treatment: Improvement of lifestyle habits and medication are the main treatments. Improvement of living and eating habits such as abstaining from smoking and alcohol, not being too full before bedtime, and holding less fried and chocolate food. Acid suppression therapy is the most commonly used medical treatment strategy in the treatment of pharyngeal reflux disease. Currently, the internationally recognized drugs of choice for anti-reflux treatment are proton pump inhibitors: omeprazole, lansoprazole, pantoprazole, rabeprazole, leminolazol, esomeprazole. Other drugs include H2 receptor blockers: imidazoles (cimetidine), furanyl thiazoles (famotidine) piperidine-methoprene. Pro-gastrointestinal motility agents, mucosal protective agents, etc.