Helicobacter pylori or H. pylori, abbreviated as Hp, is a spiral-shaped, microaerobic, Gram-negative bacillus that requires very demanding growth conditions and was first successfully isolated from gastric mucosal biopsies of patients with chronic active gastritis in 1983, and is the only microbial species known to survive in the human stomach. H. pylori disease includes gastritis, peptic ulcers, and lymphoproliferative gastric lymphoma caused by H. pylori infection. The poor prognosis for H. pylori disease is gastric cancer. It is gram-negative, microaerobic bacteria that lives in various regions of the stomach and duodenum. It causes mild chronic inflammation of the gastric mucosa and may lead to gastric and duodenal ulcers and gastric cancer. H. pylori is a microaerobic bacterium that requires 5-8% ambient oxygen and cannot grow in atmospheric or absolutely anaerobic environments. The route of transmission of H. pylori is unknown, but individuals are usually infected at an early age. Since the discovery of H. pylori on the epithelial cell surface of the gastric mucosa, it has been recognized that H. pylori is almost the only culprit that can break through this natural barrier. goodwin likens the destructive effect of H. pylori on the gastric mucosal barrier to the destruction of the “roof” causing catastrophic consequences inside the house, so it is called The “leaky house” theory. Clinical manifestations 1, the symptoms of H. pylori infection is mainly acid reflux, heartburn, as well as stomach pain, bad breath. This is mainly due to H. pylori induced gastrin crazy secretion, and the occurrence of acid heartburn, and patients with gastric ulcer disease, H. pylori is caused by the main symptom of stomach pain, halitosis one of the most direct germs is H. pylori. 2, Helicobacter pylori can cause chronic gastritis. The main clinical manifestations occur: upper abdominal discomfort, vague pain, sometimes belching, acid reflux, nausea, vomiting symptoms, the course of the disease is relatively slow, but easy to recur. 3, patients infected with H. pylori produce a variety of pathogenic factors, thus causing damage to the gastric mucosa, the occurrence of clinical disease showing diversity, and patients will mostly appear acid reflux, belching, feeling of fullness, etc., are patients infected with H. pylori than patients without H. pylori infection most times. 4, H. pylori infection is generally sometimes no particularly obvious symptoms, this is generally through the examination to determine the presence of H. pylori infection, H. pylori this pathogenic bacteria, it is easy to induce the occurrence of gastrointestinal diseases. What are the symptoms of H. pylori manifestations are these.