Some low back pain does not distinguish between morning and evening day and night pain, mostly related to abdominopelvic organ diseases, urinary system infection, kidney lesions, female gynecological inflammation, pelvic tumors, etc., can cause low back pain, and duodenal ulcer sometimes also causes radioactive pain in the low back. These low back pains do not increase with activity and do not disappear with rest, and there is no time difference. There are times when the low back pain is relieved by the patient lying in bed and turning around. The most typical early manifestation of ankylosing spondylitis is persistent low back pain (at least 3 months), unilateral and insidious, dull or intermittent, with morning stiffness, and relieved by activity. 1. Acute type of membranous nephropathy: It mostly presents with sudden onset of low back pain, often more severe, with percussion pain in the kidney area. It presents as sudden onset of lumbago, often severe, with percussion pain in the kidney area. There is a sudden increase in urine protein, often with carnal hematuria, leukocyturia, hypertension and acute renal impairment, and the kidneys on the diseased side are enlarged on ultrasound. Bilateral renal vein thrombosis may lead to oliguria and acute renal failure. Sudden onset of severe back pain: Sudden onset of back pain without obvious history of trauma, this symptom is often the main symptom of patients with urinary stones, common diseases such as kidney stones, ureteral stones, etc. 3. persistent abdominal pain or lumbago during pregnancy: the heavy symptoms of placental abruption are mainly sudden onset of persistent abdominal pain and/or lumbago and low back pain. 4. Non-ocular clinical manifestations of ankylosing spondylitis sclerosus: the most typical early manifestation is persistent low back pain (at least 3 months), unilateral and insidious, dull or intermittent, accompanied by morning stiffness and relieved by activity.