Parkinson’s disease should be treated with regular medication first, and surgery should only be considered if medication is ineffective or if the side effects of the medication are too great to be tolerated. The use of dopa drugs should again pay more attention to the following situations: Dopa drugs are currently a simple and effective drug for the treatment of Parkinson’s disease, which can lead to a significant improvement in the symptoms of 75 patients with Parkinson’s disease. Because taking this product can produce gastrointestinal, cardiovascular symptoms, mental abnormalities and involuntary movements and other side effects, and because patients often complicate other diseases and affect the application of dopa drugs, there are many cases should not apply the drug: (1) a history of peptic ulcers and active gastrointestinal tract disease patients, should not be used. Because dopa and its metabolites have a direct stimulating effect on the gastrointestinal tract, which can cause gastrointestinal bleeding, ulcers, diarrhea or constipation in a few patients. (2) People with a history of mental illness should not use it. Because it may aggravate the original psychiatric condition, it should not be used. It should not be used in the treatment of acute psychosis or in patients with severe psychosis. Long-term use of levodopa drugs, about 5 of the patients appear psychosis, such as hallucinations, delusions and delirium, a small number of patients manifested as severe depression. (3) Use with caution in people with a history of epilepsy and convulsions. Because the drug has the possibility of inducing epileptic seizures, or aggravate their pre-existing conditions. (4) Patients with closed-angle glaucoma should not use. Levodopa drugs can make glaucoma worse. (5) It should be used with caution in patients with coronary heart disease, such as angina pectoris, paroxysmal tachycardia, arrhythmia, or insufficient cerebral blood supply. (6) Levodopa drugs should be contraindicated or used with caution in patients with poorly controlled diabetes mellitus, endocrine diseases, hemolytic anemia, blood disorders and cardiac, hepatic and pulmonary insufficiency. (7) Female patients, should not be applied during their pregnancy and delivery to prevent levodopa drugs from having adverse effects on the fetus. (8) About 5 – 10 of patients with Parkinson’s disease are intolerant to the drug. Severe gastrointestinal reactions, dizziness, etc. occur before the effective dose of levodopa-based drugs is reached. It should also not be applied if it is not tolerated after repeated trials. Surgery should be considered for this subset of patients. (9) About 10 patients with Parkinson’s disease do not have a significant effect on levodopa, even if the dose is increased, it is still ineffective. Especially those patients without tremor should doubt whether the diagnosis is correct. For this group of patients, other drugs or surgery should be tried.