In case of severe coughing during TB medication, it is necessary to consider whether anti-TB treatment is ineffective or there is a possibility of drug-resistant TB bacteria, in which case sputum culture and TB drug sensitivity test should be completed. In this case, sputum culture and TB drug sensitivity test should be performed. A chest CT should also be performed to evaluate the effect of anti-TB treatment. If the sputum culture is resistant to TB, or if the chest CT shows no significant uptake or increase of TB lesions, it is usually considered that the anti-TB treatment is not effective and the anti-TB treatment regimen needs to be adjusted. In addition, if the cough is severe during medication, it is also necessary to consider whether other infections, such as viral or bacterial infections, are combined with tuberculosis. In this case, routine blood tests, C-reactive protein, calcitoninogen, sputum culture and drug sensitivity tests should be completed, and if necessary, chest CT should be completed to assess whether new infections are present. If bacterial infection is considered, anti-bacterial drugs should be added to the anti-tuberculosis medication; if viral infection is considered, additional antiviral drugs should be added, and nutrition should be enhanced to strengthen the resistance of the patient.