Congenital capillary dilatation marble-like skin AKA: congenital pancytopenia; congenital reticular cyanosis; vanLohuizen syndrome. Overview: This disease is also known as congenital pancytopenia, congenital reticular cyanosis vanLohuizen syndrome. It is associated with autosomal dominant inheritance and does not require treatment in the early stages; pulsed dye laser therapy may be tried for persistent damage. Epidemiology: congenital capillary dilatation marble-like skin is not uncommon, the incidence in newborns is about 1/3000, most of them are sporadic occasionally there are reports of familial incidence. The disease is more prevalent in females. (A) Etiology: mainly due to malformations of the capillaries and venous vessels, a small portion of which is associated with autosomal dominant inheritance, but the variation is large. Recently, the disease has also been reported to be associated with elevated levels of chorionic gonadotropin in the mother during pregnancy and transient fetal ascites. (ii) Pathogenesis: congenital malformations of capillaries and venous vessels, autosomal dominant inheritance leading to pancytopenia. (C) Pathology shows dilatation of subcutaneous capillaries and veins, but there are also those with insignificant or normal pathologic changes; Laboratory tests: There is no relevant content described. Other ancillary tests: Biopsy shows dilatation of subcutaneous capillaries and veins. (d) Clinical manifestations of the disease manifests as segmental or extensive reticular vasodilatation, with a marble-like appearance, and the limbs are most involved often secondary to ulceration, necrosis, localized atrophy and scarring (Figure 1) Complications can be accompanied by a variety of congenital malformations such as arterial ductus arteriosus, congenital glaucoma, and mental retardation. Diagnosis: The disease is diagnosed on the basis of reticular vascular damage and congenital malformations present at birth. (e) Differential diagnosis: need to be differentiated from the following diseases: 1. neonatal lupus erythematosus, onset within 3 months after birth, head and face exposure sites are more involved in the lesions are often symmetrically distributed, can be accompanied by thrombocytopenia, mild anemia, serum immunological changes and hepatomegaly. 2. Bockenheimer’s syndrome onset of childhood, usually invades a single limb, manifested as progressive dilatation and thickening of the large veins, swelling of the subcutaneous tissue, may form a large vein, and the disease can be treated by the blood vessels. The subcutaneous tissue is swollen and may form vein stones and thrombi, with growth or shortening of the affected limb. (F) Treatment: a part of the skin lesions will subside naturally, so early do not need treatment health search, for persistent damage health search, can try pulse dye laser treatment. (G) Prognosis: The prognosis is good if there is no other congenital deformity.