Brain tumor is one of the common diseases in the nervous system, which has a great risk to the function of human nervous system. In recent years, the incidence of brain tumor is on the rise, and its main clinical manifestations are: headache, vomiting, optic papillary edema and vision loss, mental and consciousness disorders and changes in vital signs. Regardless of the nature of the tumor, it will compress the brain tissue and cause intracranial pressure to rise, resulting in central nervous damage and endangering the patient’s life. Glioma Cui, male, 29 years old, had headache with left-sided hand and foot weakness and motor incoordination for two months. The patient came to XCMH for consultation, and according to his condition, the medical team designed a detailed surgical plan and used the “sculpting microsurgery” method to completely remove the tumor. After the operation, the patient survived for more than 5 years with no neurological damage and the quality of survival improved significantly, and he could continue to work. The incidence of glioma is the highest among brain tumors, accounting for about 40%-50%. Aggressive surgical treatment with systematic and regular radiotherapy and chemotherapy can improve the cure rate and control rate of glioma, prolong the survival period and improve the quality of life of patients. Craniopharyngioma Li, male, 10 years old, had a large craniopharyngioma with tumor invading the optic nerve, three ventricles, thalamus, brainstem and other important neural structures. The child’s parents went to major hospitals in major cities across the country without any obvious results. After diagnosis, the medical team used the anterior longitudinal -transcendental endplate approach to completely remove the tumor, and the child regained his sight and lived a self-care life. Craniopharyngioma is a common congenital tumor in the saddle area, accounting for about 2.5%-4% of intracranial tumors. Its peak age of onset is 5-10 years old, and craniopharyngioma accounts for about 50% of all tumors in the saddle area of children. Although craniopharyngioma is histologically benign, the difficulty of treatment makes it malignant, which seriously affects and reduces the quality of life and survival of patients, especially in children. The surgical treatment of craniopharyngioma has been one of the most challenging areas for neurosurgeons. Multiple neurofibromas Meng, female, 41 years old, had multiple neurofibromas with three tumors located in cervical 1, cervical 3 and cervical 6, among which the cervical 1 tumor invaded to the greater occipital foramen area and extended to the ventral side of the brainstem with a size of about 3.5*2.5*2 CM. The patient had severe pain, limited activities and could not take care of herself. The patient came to XUMC after going through many hospitals. After the case discussion of the whole neurosurgery department, a microsurgery plan was formulated. After the operation, the patient’s pain disappeared, and he was able to take care of himself and engage in labor. Multiple neurofibromas, also known as von Reckling’s Hodgkin’s disease, is an autosomal dominant disease caused by disorders of ectodermal and mesodermal tissues, and is characterized by multi-system and multi-organ involvement, with the central nervous system being the most obvious. This case is complex and difficult to treat, and is located around the brainstem, so the surgery is risky and can lead to life threatening at any time. The tumor was 5*4*3.3CM, invading several cranial nerves and compressing the brainstem. The patient had no neurological dysfunction and recovered well after surgery. The tumor in the rock-slope area is a tumor originating from the 5th to 11th cranial nerve exit and its medial rock bone and slope area, which is recognized as one of the most complicated tumors in the field of neurosurgery. During his doctoral studies, Dr. Liu Yong studied the “sculpting microsurgery” surgical concept created by Professor Qi Songtao. After graduating from the doctoral program, he applied his knowledge to the clinical practice of neurosurgery at XCMH and devoted himself to the treatment of brain tumors. The so-called “sculpting microsurgery” for brain tumor means “sculpting and hollowing out” along the tumor interface, which is a better way to achieve complete resection of the tumor under the premise that the surgeon’s surgical skill is high and his understanding of the tumor growth behavior is deep. This method can achieve the purpose of complete resection of the tumor and protect the brain tissue more fully, which is a true “minimally invasive neurosurgery”.