To confirm the diagnosis of rheumatic disease, the following aspects should be considered: 1. clinical manifestations: the presence of joint and muscle pain and discomfort, such as rheumatoid arthritis, patients can be combined with morning stiffness, subcutaneous nodules, small joint swelling and pain; 2. clinical signs: such as rheumatoid arthritis, small joint pain, deformation, etc., the corresponding examination can be conducted for signs; 3. laboratory tests: routine tests include routine blood, urine, blood sedimentation, C-reactive protein, blood In addition, specific tests such as antibody tests, genetic marker tests including HLA-DR4, HLA-DR1 subtype, etc.; 4. resection, biopsy, etc.