1, diarrhea, constipation, the initial symptoms are light, mucus on the surface of the stool, later the number of stools increased, often mixed with pus and blood and mucus in the stool, can be a paste-like soft stool. 2, abdominal pain, mostly confined to the left lower abdomen or lower abdomen, or no abdominal pain in mild cases. 3, indigestion, often showing anorexia, fullness, belching, epigastric discomfort, nausea, vomiting, etc.. In acute fulminant severe cases, fever, water-electrolyte imbalance, vitamin and protein loss, anemia, weight loss, etc. Zhixiong Wen, Department of General Surgery, Dongguan Shijie Hospital Diagnosis based on 1. abdominal pain, diarrhea, mucus and blood stools 2. systemic manifestations and extraintestinal manifestations. 3, repeated stool routine examination and culture did not find pathogens. 4.X-ray barium enema shows granular or nodular intestinal mucosa with coarse and disorganized folds. Diagnostic criteria ① one of the characteristic changes of colonoscopy or X-ray; ② atypical clinical manifestations, but confirmed by typical colonoscopic or X-ray manifestations or pathological biopsy; ③ exclude bacterial dysentery, amebic dysentery, schistosomiasis, intestinal tuberculosis and Crohn’s disease, radiation enteritis and other colonic inflammatory diseases.