The meridians are the channels that run the qi and blood, linking the internal organs with the body surface and various parts of the body, and are the regulatory system of human body functions. Chinese medicine said the human meridian system in the operation of the “meridian qi” is “human life movement of energy”, it exists in the form of fluctuations, is the driving force of blood circulation (Chinese medicine theory: qi for the blood of the handsome, qi line blood, qi stagnation is blood stagnation, qi deficiency is (qi stagnation will lead to blood stagnation, and qi deficiency will prevent blood from reaching the organ). Due to the weakening of “human life movement energy”, the inability to promote the operation of “meridian qi” in the meridians, resulting in meridian blockage, microcirculation barriers, poor blood supply and nourishment of the body as a whole or local cells, the cells are in a “nourishing delivery, toxic discharge”. The cells are in a state of “no nutrient delivery, no toxic discharge”. The cells are in a bad environment for a long time and cannot work normally, so that the systems in the body are in a state of disorder; the coordination relationship between the systems is out of balance. This results in various chronic diseases, of which chronic fatigue syndrome is the precursor of various chronic diseases. Therefore, adjusting the sub-healthy state from the perspective of qi and blood meridians can fundamentally lift the chronic fatigue syndrome. Chronic fatigue syndrome is the pre-development stage of various chronic diseases, and if it is not well prevented and treated, it often develops into various serious chronic diseases. The manifestation of chronic fatigue syndrome is not only fatigue and weakness, but also discomfort and pain in various parts of the body. We can help diagnose and treat chronic fatigue syndrome from the meridians through the understanding of the channels of qi and blood in the human body.