White coat hypertension is defined as increased blood pressure in the hospital and in the office, while normal blood pressure on home self-measurement or 24-hour ambulatory blood pressure monitoring. In fact, white coat hypertension is not uncommon, accounting for about 20% of all hypertensive patients and up to 40% in the elderly. Some refractory hypertension falls into the category of white coat hypertension. White coat hypertension can develop into clinical hypertension, which, like persistent hypertension, can lead to target organ damage. Therefore, white coat hypertension is receiving increasing attention from clinicians. The diagnostic criteria for white coat hypertension are systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg measured in at least 2 offices at non-same time, while the mean 24-hour ambulatory blood pressure around the clock is ≤ 135/85 mmHg, and other secondary hypertension must be excluded. Pathogenesis of white coat hypertension As with primary hypertension, the pathogenesis is unknown and may be related to sympathetic overactivity, psychological factors, abnormal immune function, gender, and metabolic disturbances. Women, neuroticism, mental stress, and people with disorders of glucolipid metabolism and high levels of tumor necrosis factor are at high risk. Damage to target organs by white coat hypertension It can cause a decrease in vascular compliance and elasticity, followed by atherosclerosis, and has an impact on cerebrovascular and cardiac functional structures and glomerular function. Its damage to target organs is lower than that of persistent hypertension. Treatment of white coat hypertension 1, active lifestyle interventions: including low salt and high potassium diet, smoking and alcohol cessation, physical exercise, weight loss, psychotherapy, etc. 2, the use of psychological debugging and mental relaxation therapy, improve their living habits, work environment, making mental relaxation. 3, drug treatment. The first can reduce sympathetic nerve activity of beta-blockers, such as metoprolol, bisoprolol, carvedilol, etc. 4.If there is already target organ damage, appropriate drug therapy is needed.