With the improvement of comprehensive treatment and level of tumor, many tumor patients can survive for a long time, especially patients with thyroid cancer, breast cancer and prostate cancer, therefore, the number of patients with bone metastasis has also increased significantly compared with the past. One of them is that many patients and doctors do not associate bone pain with tumor, which causes delay in treatment. Bone metastasis is the most common complication of tumor development, especially in advanced prostate cancer or breast cancer, about 70% of patients have bone metastasis, and in other cancers, such as lung cancer, intestinal cancer, stomach cancer, uterine cancer, rectal cancer, thyroid cancer or kidney cancer, 15-30% of patients have bone metastasis with severe pain, pathological fracture, high blood calcium and neurological compression syndrome. Tumor bone metastasis can be explained by the “seed-soil” theory, that is, normal adult bone tissue is constantly “reshaping”, and in this process, bone releases a large amount of growth factors, which provides a good environment for tumor cells to land and multiply. In this process, bone releases a large amount of growth factors, thus providing a good environment for tumor cells to land and multiply. Bone metastasis of tumors can be broadly classified into three major categories: osteolytic metastasis, osteogenic metastasis and mixed metastasis, with mixed metastasis being the most common in clinical practice. Under what circumstances should we suspect the occurrence of bone metastasis? If you have a history of malignant tumor, you should highly suspect the possibility of bone metastasis if the following symptoms occur 1. pain, which is mild and intermittent in the early stage, gradually becomes persistent and increasingly severe, and progresses rapidly; 2. swelling and masses may appear in superficial cases; 3. neurological compression symptoms: spinal metastases show symptoms of compression of spinal cord, cauda equina or nerve roots, radicular neuralgia, hyperalgesia, weakening or even loss of muscle strength, which may be accompanied by dysfunction of urinary and fecal excretion; 4. pathological fracture, which may occur when there is a slight external force; 5. primary fracture. The primary tumor symptoms: anemia, emaciation, low fever, weakness, loss of appetite, etc. When tumor bone metastasis is suspected, it should be seen by oncology specialists in time. Detailed medical history and comprehensive physical examination are very important for correct diagnosis. It is worth mentioning that the detection of bone metabolic markers is of great importance and can provide an effective means of assessment of the disease. Pathological examination is still the main means and gold standard for confirming bone metastases. Fine needle aspiration is a routine examination method, which is less destructive, painless and has a high positive rate, and is widely used in clinical practice. There are various treatments for bone metastases, and the main objectives of treatment are to reduce pain, prevent and treat fractures, maintain daily life, and improve the quality of life and prolong survival. Systemic treatment includes bisphosphonate therapy, radionuclide therapy, chemotherapy, endocrine therapy, Chinese herbal medicine and symptomatic support therapy; local treatment includes surgical and interventional surgery, external radiation therapy, etc. The Department of Medical Oncology of Shanghai Sixth People’s Hospital, combined with the Department of Orthopedics, Department of Nuclear Medicine and Department of Interventional Medicine, adopts comprehensive treatment methods for bone metastasis of tumor, combining the advantages of various disciplines, using chemotherapy, nuclear therapy, vertebroplasty, surgery and other methods to improve the quality of life and prolong the survival time of patients with bone metastasis, and also has certain experience in the clinical development of bone metabolic index test for the diagnosis and prognosis of bone metastasis. In addition, we have experience in diagnosing bone metabolic indexes and judging the prognosis of bone metastases. According to our treatment experience, although tumor bone metastasis is a sign of poor prognosis, multidisciplinary comprehensive research on its occurrence mechanism and prevention methods has been carried out in recent years, and great progress has been made. We should give up the pessimistic argument that the treatment is ineffective, adopt the principle of comprehensive treatment according to the evidence-based medicine, and individualize the treatment to deal with different patients to relieve pain and improve the quality of life. Patients with malignant tumors should also pay attention to their bone pain or other pain manifestations with a view to early detection and early treatment.