Constipation belongs to the difficult and complicated diseases of anorectal and gastroenterology, and it has always been believed that there are multiple causes of functional changes in the large intestine and anus, even secondary to partial structural changes; or that the etiology of the disease is unknown, and that there are various treatments and medications, which are ineffective or not long-lasting; because the pain of the patients can not be relieved, some doctors have to resort to surgery, and most of the therapeutic effects are still not very satisfactory. In recent years, we have found that constipation is closely related to mood disorders. In terms of etiology, constipation belongs to a group of syndromes in which mood disorders are somatized in the lower gastrointestinal tract, which are caused by a variety of factors such as neurological, psychiatric, endocrine, and gastrointestinal tract environment, which result in physio-pathological changes and cause abnormalities of sensory and motor neurotransmitters in the lower gastrointestinal tract, and a series of syndromes with defecation disorders as the main ones. Through the intervention of anti-anxiety, anti-depression and comprehensive regulation, the patients get very satisfactory treatment results, which proves the correctness of this etiological direction treatment; through standardized and reasonable regulation, the patients achieve the state of natural balance and coordination of biology, physiology and psychology, and regain the health of the body, happy mood, and smooth defecation.