The hypertension five items mainly include aldosterone, renin, angiotensin, cortisol and adrenocorticotropic hormone. The hypertension five items are suitable for the differentiation of secondary hypertension and primary hypertension. Hypertension V includes two systems: hypothalamic-pituitary-adrenocortical axis and renin-angiotensin-aldosterone system, i.e. RASS system, which mainly has the role of regulating blood pressure and balancing electrolytes. The hypertension five tests are suitable for patients with moderate or severe adolescent hypertension, and hypertensive patients who have recently developed hyperhidrosis and proteinuria. It helps to distinguish renal hypertension, primary aldosterone, pheochromocytoma and other secondary hypertension. Before doing the hypertension five tests, attention should be paid to discontinuing diuretics, ACEI, ARB and other drugs.