The congenital heart disease that predisposes to cerebral thrombosis is tetralogy of Fallot, which predisposes to the formation of attached wall thrombi in the presence of hemodynamic abnormalities within the heart, and dislodgement leading to cerebral thrombosis in the presence of atrial fibrillation. In patients with Tetralogy of Fallot, the presence of a ventricular septal defect tends to cause a left-to-right shunt, leading to an increase in blood in the left atrium, and when the blood is viscous, it tends to form an attached thrombus, which can lead to cerebral thromboembolism in the event of atrial fibrillation. In order to avoid thrombus dislodgement leading to cerebral thrombosis, you can take anticoagulant drugs, such as rivaroxaban, but the drug must be used under the guidance of a doctor, do not take it on your own, so as not to cause abnormal coagulation function. At the same time, patients with tetralogy of Fallot need to undergo surgery in time to improve their condition. It is recommended to consult a doctor in time and standardize the treatment under the doctor’s guidance.