Yesterday, with the cooperation of the Department of Anesthesiology and other related clinical and medical departments, the General Surgery Department, a national key clinical specialty of our hospital, successfully operated on and treated a patient with a huge descending duodenal tumor and gastrointestinal hemorrhage. The patient, a middle-aged male, was urgently transferred to our hospital from an outside hospital for treatment of “gastrointestinal hemorrhage and duodenal tumor ulceration”. After admission, he was treated with emergency blood transfusion and hemostasis, while gastroscopy and CT examination were completed quickly. It was found that a huge tumor was located in the inner and posterior walls of the descending duodenum, with a diameter of more than 10 centimeters, and was closely related to the first hepatic portal, hepatic artery, inferior vena cava, portal vein-superior mesenteric vein, and the trophoblastic vessels around the tumor were densely packed, which made the operation extremely risky. However, as the tumor was bleeding and ulcerated, it was difficult for other treatments to be effective, and only surgical resection of the tumor could save the patient’s life. During the surgery, we saw that the tumor had entangled the vital hepatic artery, portal vein-superior mesenteric vein and inferior vena cava, and the colon was involved. Will you decide to continue the surgery? The anatomical variation of blood vessels makes it difficult to reveal, and if the important blood vessels are damaged or the tumor is broken, the patient’s life may be in danger due to uncontrollable hemorrhage. It can be said that the journey is long, thorny and difficult! Should we give up the surgery? The patient will die soon due to tumor ulceration and bleeding! What to do? Should we retreat? Or go in? In order to save the patient, we can’t care about our own safety. As long as there is one percent of hope, we have to do 100% of our best! After 13 hours of continuous struggle, we successfully completed the whole block resection of abdominal organs such as huge duodenal tumor combined with gastric-duodenal-pancreatic-gallbladder-jejunum-colon, and completed biliary-intestinal duct, pancreatic-intestinal duct, gastrojejunal anastomosis and colonic anastomosis one by one to complete the reconstruction of digestive tract. Today the patient’s vital signs were normal and he was transferred back to the general ward from the intensive care unit. Surgical specimen of combined abdominal multi-organ resection for giant duodenal tumor.