Paroxysmal, irritating cough may be caused by cough variant asthma, or by bacteria, viruses, or atypical pathogenic bacteria. When patients develop paroxysmal, irritating cough, it is recommended to actively seek medical advice and improve relevant tests to clarify the diagnosis. Specific treatment according to the diagnosis is as follows: i. For cough variant asthma, avoid contact with allergy-prone substances, such as animal fur or pollen, and inhale glucocorticoids, commonly used drugs including Symbicort or Sulforaphane, oral leukotriene modulators, montelukast sodium, etc. Second, mycoplasma infection caused by the use of macrolide antibiotics or quinolone antibiotics. Third, caused by bacteria, use antibiotics for treatment, such as penicillin v potassium tablets, cefaclor, roxithromycin, etc. Fourth, if the patient is caused by viral infection, it is necessary to use antipyretic or antiviral drugs.