”I’ve been in pain for four days, can’t breathe, nausea and vomiting, mainly anal and leg pain, can’t lie down or sit down, cold sweat and tears flowing together, why painkillers take two tablets are not helpful, I really can’t go on, it’s an adenomyosis, why is it so painful, everyone has any way to stop the pain, help me, thanks!” ”I’m in pain and throwing up even when I don’t have my period! I can’t eat a normal meal a day! I’m a little hungry when I’m not in so much pain, but when my husband eats a bite of good food, I start throwing up and the pain starts! I feel that if I am hungry and have an empty stomach, I won’t feel so much pain! Painkillers are no longer effective! It’s worse than death.” “I’m still throwing up until I have yellow water.” When talking about adenomyosis, most people’s image is of painful periods and heavy menstrual flow. The symptoms of vomiting do not seem to be related to this disease, but clinically we encounter many patients with adenomyosis who have nausea and vomiting. Why do adenomyosis patients experience nausea and vomiting? If you have nausea and vomiting, the first step is to go to the hospital to check if you have any gastrointestinal disease or if you are pregnant. Gastrointestinal diseases and pregnancy can cause nausea and vomiting. If there is a gastrointestinal disease, it is recommended to carry out targeted treatment according to the situation, and the nausea and vomiting will disappear naturally after treatment. If you are pregnant (you should pay special attention to whether or not you are pregnant until recently), then it is recommended that you seek medical attention for fetal preservation as soon as possible, because adenomyosis patients are very prone to miscarriage and fetal abortion due to the poor environment of the uterine cavity. The second rule is to exclude nausea and vomiting triggered by medication. As adenomyosis is painful, some patients are in so much pain that they can’t stand it, so the only solution is to stop the pain. Every adenomyosis patient is expected to have a lot of painkillers and birth control pills at home! The actual fact is that some of the drugs have an irritating effect on the stomach, and taking painkillers and birth control pills for a long time can cause nausea and vomiting. It may also be caused by adenomyosis itself. When a patient with adenomyosis has her period, the endometrium thickens under the action of estrogen, and during the thickening process of the endometrium, prostaglandins are produced, which are molecular compounds secreted by several organs, including the uterus. Prostaglandins can excite the uterus, causing strong muscle contractions, uterine ischemia, lack of oxygen and pain felt. Large amounts of prostaglandins entering the bloodstream can lead to muscle contractions in the gastrointestinal tract, which in turn can induce nausea and vomiting, abdominal pain, etc. Therefore, nausea and vomiting symptoms in patients with adenomyosis are often caused by elevated prostaglandins and unbearable menstrual pain.