Hello doctor, ca125 was 39 the year before last, 56 last year, 96 this year, with adenomyosis, is this considered normal, does it need to be dealt with, and if so, what should be done? Hello, this netizen, three years of continuous steady elevation is considered a relatively normal phenomenon, do not worry. I wonder how big your uterus is? Is it anemic? Are the menstrual cramps severe? If you have a large uterus, anemia, and severe intolerable menstrual cramps. If you meet one of the conditions, surgery is recommended. You can preserve the uterus, dig out the lesions, and after the surgery, you will no longer have dysmenorrhea and your menstrual flow will be reduced. For patients with adenomyosis. Most patients with adenomyosis have an elevated CA125. However, the specifics are different per patient, and the average patient has around 50 or 60, but also more than 100, and more than 200, and we have even encountered more than 1,000. But these are all benign, and no malignant ones have been found. But if your CA125 value suddenly rises sharply and dramatically over a period of time (within a few months), for example, from dozens to hundreds all of a sudden, then you should be careful. Because we can not rule out that there will be individual patients with adenomyosis whose condition will worsen. What should be done at this time? It is recommended to do a diagnostic scraping of the uterine lining to see if there is any lesion, of course, the annual physical examination of women’s health is still a must. However, CA125 is only an observational index, and its value cannot be used to directly diagnose the disease; further diagnosis of the disease requires comprehensive tests. For example, in the past few years, we have encountered many patients with adenomyosis combined with coelomic sacs, and found that a few of them had cancerous changes. However, none of them had a CA125 value of more than 200, and a small number of patients with adenomyosis did not have a high CA125 value either. Therefore, the results of pathologic examination are far more accurate and reliable than CA125, which is more often used as an auxiliary reference, and we often use it for the detection of the disease and the evaluation of the efficacy of treatment.