A few days ago, the patient Chang Xihui with a very grateful mood, reluctantly left the 309 Hospital Hepatobiliary Surgery Department full of feelings, satisfied to return to his hometown in Shanxi. It is reported that this is the first case of laparoscopic radiofrequency ablation of the spleen performed in our hospital, and also the first time for our hospital to treat patients with Gaucher’s disease. The patient was a 37-year-old male with recurrent leukocyte and platelet drops, and was found to have an enlarged spleen, but the cause could not be determined. From then on, the patient moved from one place to another, and was diagnosed with Gaucher’s disease after repeated examinations at the Union Hospital, 301 Hospital, Wuhan Tongji Hospital, and many other hospitals. This is a very rare familial autosomal genetic disease, characterized by an enlarged spleen, a continuous drop in white blood cells and platelets, abnormal liver function, and “Gaucher’s cells” seen under the microscope of liver and spleen biopsy. Due to the long duration of the disease, the patient’s spleen had grown from the size of a banana to the pelvis, with the longest length reaching 33.9cm. The patient lived carefully every day, fearing that the spleen would rupture and bleed at any time, which would be life-threatening. In order to solve the problem of splenic hyperfunction and splenomegaly and unwilling to undergo open surgery, the patient consulted with several hospitals and finally found Dr. Li Hucheng of the Hepatobiliary Surgery Department of the Transplantation Center through various channels and was admitted to the Department of Hepatobiliary Surgery to receive treatment. Dr. Hucheng Li, deputy director of the Hepatobiliary Surgery Department of the Transplantation Center, examined the patient in detail and systematically, and gave him meticulous care in life and spirit, and communicated with the patient around the diagnosis and treatment of Gaucher’s Disease. After repeated discussions and research, with the support of Director Zou Yiping, it was decided to give up the traditional open splenectomy and combine two minimally invasive techniques, laparoscopy and radiofrequency ablation, which not only achieved the purpose of further clarifying the diagnosis and lowering the function of the spleen, but also avoided the huge trauma and pain brought by a 30cm incision in the abdomen to the patient. On May 27, Deputy Director Li Hucheng, with the assistance of Drs. Huang Hui, Wang Ruiguan, Cai Chongqi, and Wang Yan, only made two 1.0cm incisions and one 0.5cm incision in the patient’s abdomen, and under the supervision of laparoscopy, he used a radiofrequency needle with a diameter of only 2mm, directly inserted it into the parenchyma of the spleen, opened the radiofrequency needle inside the spleen, and stretched out the 9 electrodes, and then performed the ablation of the giant spleen in order from the upper pole downward, and each time, the spleen could be destroyed by 7cm. As the spleen had grown all over the abdominal cavity, it seriously affected the microscopic field of view, in addition, the pathological spleen was very brittle, the patient’s coagulation mechanism was impaired, intraoperative hemorrhage was ferocious, so the difficulty of the operation increased significantly. Director Li Hucheng overcame all the difficulties, used different directions of cross radiofrequency, electrocoagulation and radiofrequency combination of methods, lasted 4 hours, 7 consecutive radiofrequency ablation, and successfully controlled the bleeding of the spleen. The patient’s postoperative recovery was smooth. The follow-up ultrasound and enhanced CT showed a large necrotic area in the spleen, which accounted for about 1/3 of the whole spleen, the hypersplenism was relieved, and the white blood cells and platelets began to rebound, and the patient was discharged from the hospital after 13 days of the operation. Laparoscopic radiofrequency ablation of the spleen is another advancement after laparoscopic radiofrequency ablation of the liver. Since the spleen is more prone to bleeding than the liver and radiofrequency ablation carries greater risks, fewer units in China perform laparoscopic spleen radiofrequency ablation. The successful implementation of the first case of laparoscopic radiofrequency ablation of the spleen in our hospital has accumulated valuable experience for the future development of radiofrequency ablation of splenic diseases as well as minimally invasive treatment of the spleen under laparoscopy, and has laid the foundation for further in-depth work in this field.