Liver metastasis of small cell lung cancer indicates that the cancer has already reached the advanced stage. Generally speaking, the combination of chemotherapy and radiotherapy, the joint application of immune checkpoint inhibitors, and other medications and minimally invasive interventional therapy should be considered for comprehensive treatment. Liver metastasis of small cell lung cancer, the condition is more serious, the patient’s appetite begins to decrease, accompanied by obvious emaciation, ascites as well as decrease of albumin, etc., it is necessary to actively cooperate with doctors to carry out systemic treatment, including chemotherapy, radiotherapy, and joint application of immune checkpoint inhibitors, such as atilizumab injection, etc., to control the condition. If symptoms of pain occur during chemotherapy, pain relieving drugs, such as morphine extended-release tablets, can also be used under the guidance of the doctor to relieve pain. For residual single lesions, minimally invasive interventional therapy, such as hepatic artery chemoembolization, can be considered. If hepatic artery chemoembolization is performed, it is recommended to cooperate with professional oncologists as soon as possible to carry out comprehensive treatment to control the disease, prolong the patient’s survival period as much as possible and improve the quality of life.