Patients with stage I colon cancer do not need any adjuvant therapy after surgery, and close observation is sufficient, including (T1-2N0M0 stage) 2. Patients with stage II colon cancer combined with high-risk factors need chemotherapy, including (T3-4N0M0 stage) High-risk factors include: (1) less than 12 lymph nodes detected; (2) poor pathological differentiation type; (3) vascular and nerve (4) intestinal obstruction (5) intraoperative perforation (6) positive cut margins (7) T4 stage 3, stage III colon cancer patients must be treated with postoperative adjuvant chemotherapy (positive lymph node metastases) Choice of chemotherapy regimen: mFOLFOX6 (oxaliplatin, 5-FU/LV); biweekly regimen; CapeOx (oxaliplatin, capecitabine); three-weekly regimen; both regimens are equivalent in adjuvant therapy, and clinical The choice can be made according to patient compliance, economic benefits and other specific circumstances. Duration of chemotherapy: 1. The recommended duration of postoperative adjuvant chemotherapy is 6 months, with a total of 12 sessions for the biweekly regimen and 8 sessions for the three-week regimen. 2, the first postoperative chemotherapy start time: postoperative adjuvant chemotherapy time is not unified regulations or recommendations, the general saying is “start as soon as possible after recovery”, the routine in our hospital is 3-4 weeks after surgery to start adjuvant chemotherapy. survival rate decreased by about 12%. Therefore, it is important to start as soon as the body recovers after surgery.