1, the use of different drugs “closed” generally use a higher concentration of anesthetics, while “nerve block” generally only use a lower concentration of anesthetics to achieve the therapeutic effect, so there will be no limb dysfunction; in addition to the general The “closed” injection drug generally contains only anesthetic, while the “nerve block” generally uses some direct therapeutic effect on the lesion tissue drugs, as well as neurotrophic drugs. 2, the site is different: the site of the closed injection of drugs is the pain point, equivalent to the target area of the nerve block block, nerve block is to inject drugs according to the law of travel and innervation of nerves, such as the commonly used clinical stellate ganglion block, the treatment site is in the neck, but can treat neurasthenia, insomnia, sympathetic cervical spondylosis, hypertension, facial paralysis and a dozen other difficult diseases. 3, the technical difficulty and efficacy of the operation of different “closed” is only the injection of drugs to the proximal end of the lesion or nearby to achieve the purpose, or even “which pain hit which”, the accuracy requirements are not high. While the “nerve block” is a long period of professional training to properly implement the branch operation, therefore, before treatment must be clearly diagnosed, to find the precise location of the lesion, the heart must be accurately injected into or around the lesion tissue, in order to achieve the desired effect of treatment. 4, different requirements for diagnosis Generally speaking, “closed” therapy is based on the pain closed to block the continuation of the pain arc, the diagnosis before injection is not necessarily clear, the injection site is not necessarily the lesion, so the diagnosis is not clear can also be carried out, often pain relief but the lesion can still have development. In contrast, before administering “nerve block” therapy, the diagnosis must be clear and the location of the lesion must be known, and the drug must be injected into the lesion. Therefore, the efficacy of the two treatments cannot be compared to each other. The characteristic of “nerve block” therapy is that “the most needed drugs are delivered in the most direct way to the most needed place”. Therefore, “nerve block” is a non-surgical treatment method that concentrates the advantages of medicine and fights a war of annihilation and rapid warfare, with fast results and high efficacy, and fewer visits to the hospital by patients. As a result, they are two completely unrelated concepts and two very different treatment methods. As the most basic means of pain treatment, nerve block therapy can play a greater role in relieving the personal pain for the majority of pain patients.