Cholinergic urticaria can be partially self-healing, mild symptoms of skin symptoms can disappear within one hour, the cause is clear, after removing the cause can be cured, the cause is unknown, after treatment, most of the symptoms can be alleviated, but can not be cured. Cholinergic urticaria is caused by a variety of factors in the deep body temperature rises, prompting the cholinergic nerve impulse release of acetylcholine, the role of mast cells and the onset. In mild cases, the symptoms usually disappear in 1 hour. If the cause is clear and eliminated, it can be cured after medication, if the cause is unknown and cannot be eliminated, the symptoms can be reduced after treatment. Cholinergic urticaria is generally based on drug treatment, antihistamines are commonly used drugs, such as loratadine, cetirizine, etc., at the same time can be used in conjunction with anticholinergic drugs, such as brompropylamine tylenol, scopolamine butylbromide, etc., but also can be used externally with glycerol and other lotions, to improve the itchy skin symptoms. Patients with cholinergic urticaria are advised to go to the hospital in time for professional treatment under the guidance of the doctor.