White spots may grow anywhere on the body at the earliest stage, but are more common on the face and extremities. White spots are not a disease name, but a clinical manifestation, mainly seen in vitiligo, post-inflammatory hypopigmentation, vulvar leukoplakia, halo nevus and other pigment-reducing skin diseases. The cause of the disease is not clear in most patients, it may have some correlation with autoimmunity and is generally an acquired disease, among which vitiligo is more common. Vitiligo is most likely to occur in the face, finger backs, forearms, neck and external genitalia at the earliest stage. The first stage of vitiligo is on the face, finger backs, forearms, neck and external genitalia, while albinism is a congenital pigment reduction or lack of disease, mainly manifested as large patches of white spots all over the body, which need to avoid sunlight exposure to avoid discomfort. After the appearance of white spots, patients need to go to the hospital dermatology department in time to clarify the nature of the white spots, and timely symptomatic treatment to avoid further expansion of the white spot area.