Most Parkinson’s patients are treated with medication, which can be taken orally when the medication works well. After 4-5 years of medication, the effectiveness of medication has significantly decreased and the condition has gradually worsened, brain pacemaker treatment can be considered. Brain pacemaker can not only improve the patient’s symptoms, improve the quality of life, but also reduce the dose and variety of drugs, reduce the complications caused by drugs. What kind of Parkinson’s patients are suitable for surgical treatment? Need to meet the following conditions: 1, diagnosis of primary Parkinson’s disease, not Parkinson’s syndrome, for hereditary Parkinson’s disease or a variety of gene mutation Parkinson’s disease, as long as the effect of the treatment of Medoxomil is good, can also be operated on, the average rate of improvement of about 60-70% after surgery. For Parkinson’s syndrome, if the effect of long-term drug treatment is not satisfactory, brain pacemaker treatment can also be considered, but the effect is far less than Parkinson’s disease. 2.Duration of the disease is more than 5 years (the average patient responds well to methyldopa within 5 years), for patients with primary Parkinson’s disease, predominantly tremor, unsatisfactory improvement of tremor by standardized drug therapy, and tremor seriously affects the patient’s quality of life, after evaluation can be relaxed to the duration of the disease has been completed more than 3 years. 3, in terms of age, patients should be no more than 75 years old; elderly patients can be relaxed to about 80 years old after individualized assessment of benefits and risks; we have done more than 20 cases of patients over 80 years old, with good results and no major complications. 4, in terms of medication, there used to be good efficacy for compound levodopa, Medopa shock test, improvement rate of more than 30%; optimal medication has been carried out; at present, it cannot satisfactorily control the symptoms, efficacy has decreased significantly, and there exists the phenomenon of on-off switching, or anisometropia. 5, patients and their families have reasonable expectations of surgery: (1) surgery can not solve all the symptoms, some of the symptoms can not be relieved by surgery; (2) can not be a radical cure for Parkinson’s disease, the disease will progress; (3) not all patients are able to reduce or stop medication after surgery.