Polyarteritis nodosa is a kind of necrotizing vasculitis involving medium and small arteries, which is mostly treated with glucocorticosteroids such as methylprednisolone and immunosuppressants such as cyclophosphamide. Polyarteritis nodosa is a kind of autoimmune vasculitis with various clinical manifestations, which can be manifested as fever, malaise, numbness, edema, and the examination can find peripheral neuritis, hematuria, diarrhea, and other systemic multiorgan lesions. Nodular polyarteritis requires early diagnosis and early treatment, and the main treatment method is drug therapy. Glucocorticosteroids are the drugs of choice for the treatment of polyarteritis nodosa, including prednisone and methylprednisolone. Immunosuppressants such as cyclophosphamide, azathioprine and methotrexate are also commonly used to treat polyarteritis nodosa. If nodular polyarteritis is present, it is recommended to visit a hospital promptly for early and regular treatment.