Aspirin is not only very inexpensive and affordable for everyone, it is also the most economically efficient of the cardiovascular disease prevention drugs. A British study showed that for every case of cardiovascular event prevention, antihypertensive drugs and lipid-lowering drugs cost 5.28 times and 17.14 times more than aspirin, respectively. A 2005 NIH study of 40,000 healthy American women who took aspirin for 10 years showed that aspirin reduced the incidence of first strokes by 1/4, with more benefits for people with high blood pressure and diabetes. Aspirin is now the most essential drug for the prevention and treatment of cardiovascular disease. Patients with atherosclerotic disease (coronary artery disease, cerebral infarction, peripheral vascular disease) and those at high risk for atherosclerotic disease (hyperglycemia, hyperlipidemia, hypertension, advanced age, smoking, obesity, family history of coronary artery disease, atrial fibrillation) should consult a physician and consider taking aspirin as long as there are no contraindications. Although aspirin has many of the above-mentioned efficacy and advantages, there are still many problems in the standardized use of aspirin in China. 1. Taking aspirin can reduce mortality and the risk of recurrence in patients with cardiovascular and cerebrovascular diseases. Research confirms that: patients with cardiovascular and cerebrovascular diseases (coronary heart disease, cerebral infarction, peripheral artery disease) taking aspirin for a long time can not only reduce mortality, but also reduce the risk of disease recurrence. Aspirin in patients with stable angina can reduce the incidence of various cardiovascular events and mortality by 1/3. Patients with unstable angina benefit even more from aspirin, reducing the incidence of myocardial infarction and mortality by 51%. Early use of aspirin in patients with acute myocardial infarction saves 25 lives per 1000 patients and prevents 10-15 recurrent myocardial infarction and cerebral infarction. Recommendation: Patients with cardiovascular and cerebrovascular diseases should consult their physicians and should use aspirin early and long-term as long as there are no contraindications. 2.People with high risk factors for cardiovascular and cerebrovascular diseases can take aspirin to prevent the occurrence of cardiovascular and cerebrovascular diseases. Aspirin is not suitable for all people without cardiovascular disease, but for people with a variety of risk factors, aspirin can effectively prevent the occurrence of disease. Since 1988, six clinical studies have been conducted to examine whether people without cardiovascular disease should take aspirin, most notably the aforementioned “Men’s Physician Study” and the “Women’s Health Study”. The results of all six studies showed that aspirin reduced morbidity and mortality from first cardiovascular events, and that the higher the risk of disease, the greater the benefit. Recommendation: Not everyone needs to take aspirin, but aspirin should be considered for people with multiple risk factors (high academic sugar, hyperlipidemia, hypertension, advanced age, smoking, obesity, family history of coronary heart disease, atrial fibrillation, etc.) in the high Fengxian population. The general principle is that aspirin should be considered for people under 50 years of age with a combination of 2 risk factors, or over 50 years of age with a combination of one risk factor. 3, long-term use of aspirin should be selected enteric volume type. At present, there are three main dosage forms of aspirin: regular aspirin, enteric aspirin and aspirin effervescent tablets. These three dosage forms are suitable for different people and for different diseases. The main side effect of aspirin is irritation of the gastric mucosa. Non-enteric tablets (such as regular aspirin or effervescent tablets) dissolve in the stomach, which can irritate the gastric mucosa and can only be taken for a short period of time, mainly for relieving fever and analgesia. Enteric tablets are coated with a protective layer of antacid in ordinary aspirin. It does not dissolve in the acidic environment of the stomach, but only in the attenuated environment of the intestine, which can significantly reduce the side effects in the gastrointestinal tract and is the best dosage form for long-term use. Of course, the quality of enteric tablets is also important. Even if the poor quality ones meet the national enteric quality standard, there will still be a small amount of dissolution in the stomach, which will lead to increased side effects. Recommendation: Long-term use of aspirin should be in enteric form. With one exception, in the acute phase of the disease, in order to make the drug work as soon as possible, the first dose should take ordinary aspirin tablets, and if it is an enteric-soluble tablet, it should be chewed and taken. 4. The best dose of aspirin for long-term use is 100 mg/day. Many people know that small doses of aspirin should be used to prevent cardiovascular disease. But what exactly is the range of small dose? In 2002, the British Medical Journal published an article summarizing the results of 287 experiments around the world, which concluded that the best effect is achieved by taking 75-150 mg of aspirin per day, and it is uncertain whether it is effective below 75 mg per day, while doses higher than 325 mg/day are less effective due to increased side effects. Data show that half of the patients in China are using less than 75 mg per day of ineffective dose. Even in the outpatient clinics of large hospitals such as Beijing and Shanghai, more than 20% of patients are still using too low an ineffective dose of 20 or 25 mg per day. Therefore, it is very important to increase the learning and promotion efforts. Recommendation: There is a consensus in the medical community that “low dose” aspirin means 75 to 325 mg per day. The optimal amount for long-term use is 100 (75-150) mg per day. 150-250 mg per day is mainly used in the acute phase.