In recent years, the incidence of lower extremity atherosclerosis is on the rise, but many patients do not receive timely and correct treatment, the general public and even primary care workers lack understanding of the disease, and even delayed treatment, and it is not uncommon for patients to come to the clinic only after the lower extremity necrosis. It is very important to choose the appropriate treatment according to the patient’s specific condition. Professional vascular surgeons should refer to the standard treatment guidelines to provide suitable treatment plans for patients, including drug therapy combined with standardized exercise, lower extremity artery interventional balloon dilation or stenting treatment, artificial blood vessel or autologous vein bypass surgery, or even amputation treatment. Postoperative follow-up is very important, 3 months, 6 months, 1 year after surgery, and 1 half-yearly follow-up thereafter. This includes vascular examination and ultrasound examination to detect restenosis or occlusive lesions in time so that proper treatment can be arranged early. It should be recognized that atherosclerosis occlusive disease is not curable, and strict medical treatment to control risk factors is especially important to maintain one’s own vascular condition, prolong vascular patency as long as possible, exercise new collateral vessels, achieve long-term limb preservation, and improve quality of life.